The Complexities Of Formulation And Development Of Tablets

by | Oct 10, 2017 | Drug Addiction

One of the most common dosage forms used for oral medication is the tablet. Today, with various options for tablets including multi-layer, targeted release, and even micro tablets, there are a lot of different steps and verifications required.

The formulation and development of tablets are dependent on many different factors, and all of these factors have to correlate with the objectives of the pharmaceutical company. The best formulation for a tablet in the lab may not meet the needs of the end user. Having the ability to create the ideal form and combination of active and inactive ingredients in the tablet will be critical to success.

Understanding the Options

It will take an experienced team of researchers to effectively and efficiently determine the correct formulation and development of tablets. As this is not a process that should be rushed or that can be cut short, working with an experienced team of chemists, researchers and scientists will allow for streamlining of the possibilities and options to more rapidly narrow down the correct formulation.

The key for any formulation and development of tablets is to avoid any interactions between the ingredients. This is complicated if there is one active ingredient, but in the development of multi-layer tablets, there may be several active ingredients to consider.

The more complex the active ingredients are in the medication, the more experience the formulation team will need to be.

Clear Collaborative Processes

It will also be essential for the pharmaceutical company and the contract drug manufacturer completing the preformulation, formulation and development stages of the new drug to work collaborative together.

The lines of communication between the two partners in the manufacturing process should be open with the ability to share information and data in a way that benefits the process as well as the end results.

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