The Anti-CD3 antibody is designed to react with the antigen of the same name in the intracytoplasmic portion expressed by T-cells. It can stain human T-cells in the medulla and cortex of the thymus, as well as in the peripheral lymphoid tissues. It is suitable to stain both neoplastic and normal T-cells, as well.
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The P53 antibody is a tumor-suppressing gene that is expressed in many tissue types and can be used to regulate cell replication, growth, and apoptosis. It can bind to the SV40T, MDM2, and human papiulloma virus, as well. It can also sense damage to the DNA and may help with repairs. Mutations involving this antigen is found in many malignant tumors, such as ovarian, bladder, colon, melanoma, lung, and breast tumors.
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